Phosducin-like protein 2 (PDCL2)
Homo sapiens — UniProt Q8N4E4
Data last refreshed: (UniProt release unknown)
Key facts
Phosducin-like protein 2 (PDCL2) is a protein from Homo sapiens identified by UniProt accession Q8N4E4, 241 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.
- UniProt accession: Q8N4E4; gene symbol PDCL2.
- Organism: Homo sapiens.
- Length: 241 amino acids.
- Top disease associations (Open Targets): male infertility, erythrocyte count and C-reactive protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosducin-like protein 2 |
|---|---|
| UniProt accession | Q8N4E4 |
| Gene | PDCL2 |
| Organism | Homo sapiens |
| Length | 241 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (149)
Diseases linked to this target (Open Targets).
- male infertility · score 0.33
- erythrocyte count · score 0.24
- C-reactive protein measurement · score 0.15
- IGF-1 measurement · score 0.14
- BMI-adjusted waist-hip ratio · score 0.14
- waist-hip ratio · score 0.12
- lymphocyte count · score 0.10
- azoospermia · score 0.10
- BMI-adjusted waist circumference · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4E4-F1 | alphafold | PREDICTED | 80.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4E4.
Amino-acid sequence (241 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PDCL2?
The strongest Open Targets associations for PDCL2 are male infertility, erythrocyte count, C-reactive protein measurement, IGF-1 measurement and BMI-adjusted waist-hip ratio.
How long is the PDCL2 protein?
The Homo sapiens PDCL2 protein (UniProt Q8N4E4) is 241 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4E4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4E4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.