Spermatogenesis associated 6-like protein (SPATA6L)
Homo sapiens — UniProt Q8N4H0
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis associated 6-like protein (SPATA6L) is a protein from Homo sapiens identified by UniProt accession Q8N4H0, 392 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q8N4H0; gene symbol SPATA6L.
- Organism: Homo sapiens.
- Length: 392 amino acids.
- Top disease associations (Open Targets): neutrophil count, mean platelet volume and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis associated 6-like protein |
|---|---|
| UniProt accession | Q8N4H0 |
| Gene | SPATA6L |
| Organism | Homo sapiens |
| Length | 392 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.37
- mean platelet volume · score 0.31
- erythrocyte count · score 0.30
- response to antipsychotic drug · score 0.30
- leukocyte count · score 0.30
- platelet crit · score 0.26
- mean corpuscular hemoglobin concentration · score 0.24
- mean corpuscular hemoglobin · score 0.20
- mean corpuscular volume · score 0.19
- myeloid white cell count · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4H0-F1 | alphafold | PREDICTED | 56.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4H0.
Amino-acid sequence (392 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATA6L?
The strongest Open Targets associations for SPATA6L are neutrophil count, mean platelet volume, erythrocyte count, response to antipsychotic drug and leukocyte count.
How long is the SPATA6L protein?
The Homo sapiens SPATA6L protein (UniProt Q8N4H0) is 392 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4H0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4H0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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