Mitochondrial import receptor subunit TOM5 homolog (TOMM5)
Homo sapiens — UniProt Q8N4H5
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) is a protein from Homo sapiens identified by UniProt accession Q8N4H5, 51 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q8N4H5; gene symbol TOMM5.
- Organism: Homo sapiens.
- Length: 51 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lipoprotein-associated phospholipase A(2) measurement and metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial import receptor subunit TOM5 homolog |
|---|---|
| UniProt accession | Q8N4H5 |
| Gene | TOMM5 |
| Organism | Homo sapiens |
| Length | 51 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.15
- lipoprotein-associated phospholipase A(2) measurement · score 0.13
- metabolite measurement · score 0.04
- idiopathic CD4 lymphocytopenia · score 0.04
- idiopathic pulmonary fibrosis · score 0.04
- immunodeficiency 51 · score 0.04
- immunodeficiency 75 · score 0.04
- osteoporosis-pseudoglioma syndrome · score 0.04
- immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia · score 0.04
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4H5-F1 | alphafold | PREDICTED | 87.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4H5.
Amino-acid sequence (51 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TOMM5?
The strongest Open Targets associations for TOMM5 are neurodegenerative disease, lipoprotein-associated phospholipase A(2) measurement, metabolite measurement, idiopathic CD4 lymphocytopenia and idiopathic pulmonary fibrosis.
How long is the TOMM5 protein?
The Homo sapiens TOMM5 protein (UniProt Q8N4H5) is 51 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4H5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4H5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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