Reprimo-like protein (RPRML)
Homo sapiens — UniProt Q8N4K4
Data last refreshed: (UniProt release unknown)
Key facts
Reprimo-like protein (RPRML) is a protein from Homo sapiens identified by UniProt accession Q8N4K4, 120 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q8N4K4; gene symbol RPRML.
- Organism: Homo sapiens.
- Length: 120 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hematocrit and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Reprimo-like protein |
|---|---|
| UniProt accession | Q8N4K4 |
| Gene | RPRML |
| Organism | Homo sapiens |
| Length | 120 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- hematocrit · score 0.27
- diastolic blood pressure · score 0.26
- hemoglobin measurement · score 0.24
- atrial fibrillation · score 0.22
- hypertension · score 0.22
- chronic obstructive pulmonary disease · score 0.21
- cardiac arrhythmia · score 0.21
- atrial flutter · score 0.21
- chronotype measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4K4-F1 | alphafold | PREDICTED | 58.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4K4.
Amino-acid sequence (120 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RPRML?
The strongest Open Targets associations for RPRML are neurodegenerative disease, hematocrit, diastolic blood pressure, hemoglobin measurement and atrial fibrillation.
How long is the RPRML protein?
The Homo sapiens RPRML protein (UniProt Q8N4K4) is 120 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4K4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4K4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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