Transmembrane protein 151A (TMEM151A)
Homo sapiens — UniProt Q8N4L1
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 151A (TMEM151A) is a protein from Homo sapiens identified by UniProt accession Q8N4L1, 468 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q8N4L1; gene symbol TMEM151A.
- Organism: Homo sapiens.
- Length: 468 amino acids.
- Top disease associations (Open Targets): genetic disorder, apolipoprotein A 1 measurement and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 151A |
|---|---|
| UniProt accession | Q8N4L1 |
| Gene | TMEM151A |
| Organism | Homo sapiens |
| Length | 468 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.19
- apolipoprotein A 1 measurement · score 0.09
- high density lipoprotein cholesterol measurement · score 0.09
- body weight · score 0.06
- lean body mass · score 0.06
- body fat percentage · score 0.04
- mathematical ability · score 0.04
- insomnia · score 0.03
- self reported educational attainment · score 0.03
- visceral adipose tissue measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4L1-F1 | alphafold | PREDICTED | 72.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4L1.
Amino-acid sequence (468 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM151A?
The strongest Open Targets associations for TMEM151A are genetic disorder, apolipoprotein A 1 measurement, high density lipoprotein cholesterol measurement, body weight and lean body mass.
How long is the TMEM151A protein?
The Homo sapiens TMEM151A protein (UniProt Q8N4L1) is 468 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4L1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4L1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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