Spermatid maturation protein 1 (SPEM1)

About Spermatid maturation protein 1

Spermatid maturation protein 1 (SPEM1) is a protein from Homo sapiens identified by UniProt accession Q8N4L4, 309 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	Spermatid maturation protein 1
UniProt accession	Q8N4L4
Gene	SPEM1
Organism	Homo sapiens
Length	309 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.37
sitting height measurement · score 0.12
azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.07
spermatogenic failure 72 · score 0.07
spermatogenic failure 18 · score 0.07
spermatogenic failure 46 · score 0.07
spermatogenic failure 27 · score 0.07
spermatogenic failure 65 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N4L4-F1	alphafold	PREDICTED	53.59	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4L4.

Amino-acid sequence (309 residues)

MAMVERPRPE WASYHNCNSN SCQDLGNSVL LLLGLIICIN ISINIVTLLW SRFRGVLYQV FHDTICEKEA PKSSLLRKQT QPPKKQSSPA VHLRCTMDPV MMTVSPPPAH RHRRRGSPTR CAHCPVAWAP DTDDEKPHQY PAICSYHWDV PEDWEGFQHT QGTWVPWSQD APESPPQTIR FQPTVEERPL KTGIWSELGL RAYVYPVNPP PPSPEAPSHK NGGEGAVPEA EAAQYQPVPA PTLGPAVIPE FSRHRSSGRI VYDARDMRRR LRELTREVEA LSGCYPLASG SSTAEETSKN WVYRSLTGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards