Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4)
Homo sapiens — UniProt Q8N4Q1
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4) is a protein from Homo sapiens identified by UniProt accession Q8N4Q1, 142 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8N4Q1; gene symbol CHCHD4.
- Organism: Homo sapiens.
- Length: 142 amino acids.
- Top disease associations (Open Targets): insulin like growth factor measurement, IGF-1 measurement and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial intermembrane space import and assembly protein 40 |
|---|---|
| UniProt accession | Q8N4Q1 |
| Gene | CHCHD4 |
| Organism | Homo sapiens |
| Length | 142 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- insulin like growth factor measurement · score 0.24
- IGF-1 measurement · score 0.24
- heel bone mineral density · score 0.24
- red blood cell density measurement · score 0.21
- protein measurement · score 0.17
- neoplasm · score 0.09
- pulmonary arterial hypertension · score 0.07
- lung adenocarcinoma · score 0.07
- erythrocyte count · score 0.07
- metabolite measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4Q1-F1 | alphafold | PREDICTED | 75.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4Q1.
Amino-acid sequence (142 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHCHD4?
The strongest Open Targets associations for CHCHD4 are insulin like growth factor measurement, IGF-1 measurement, heel bone mineral density, red blood cell density measurement and protein measurement.
How long is the CHCHD4 protein?
The Homo sapiens CHCHD4 protein (UniProt Q8N4Q1) is 142 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4Q1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4Q1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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