MARVEL domain-containing protein 2 (MARVELD2)
Homo sapiens — UniProt Q8N4S9
Data last refreshed: (UniProt release unknown)
Key facts
MARVEL domain-containing protein 2 (MARVELD2) is a protein from Homo sapiens identified by UniProt accession Q8N4S9, 558 residues long. MolForge cross-references it against 0 known binders and 147 disease associations.
- UniProt accession: Q8N4S9; gene symbol MARVELD2.
- Organism: Homo sapiens.
- Length: 558 amino acids.
- Top disease associations (Open Targets): deafness, hearing loss, autosomal recessive and Rare genetic deafness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | MARVEL domain-containing protein 2 |
|---|---|
| UniProt accession | Q8N4S9 |
| Gene | MARVELD2 |
| Organism | Homo sapiens |
| Length | 558 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (147)
Diseases linked to this target (Open Targets).
- deafness · score 0.67
- hearing loss, autosomal recessive · score 0.64
- Rare genetic deafness · score 0.45
- urate measurement · score 0.39
- nonsyndromic genetic hearing loss · score 0.37
- hearing loss · score 0.37
- Abnormality of the ear · score 0.34
- ear malformation · score 0.34
- Hearing impairment · score 0.33
- creatinine measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4S9-F1 | alphafold | PREDICTED | 66.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4S9.
Amino-acid sequence (558 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MARVELD2?
The strongest Open Targets associations for MARVELD2 are deafness, hearing loss, autosomal recessive, Rare genetic deafness, urate measurement and nonsyndromic genetic hearing loss.
How long is the MARVELD2 protein?
The Homo sapiens MARVELD2 protein (UniProt Q8N4S9) is 558 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4S9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4S9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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