Carboxypeptidase A6 (CPA6)
Homo sapiens — UniProt Q8N4T0
Data last refreshed: (UniProt release unknown)
Key facts
Carboxypeptidase A6 (CPA6) is a protein from Homo sapiens identified by UniProt accession Q8N4T0, 437 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q8N4T0; gene symbol CPA6.
- Organism: Homo sapiens.
- Length: 437 amino acids.
- Top disease associations (Open Targets): familial temporal lobe epilepsy 5, Febrile seizure (within the age range of 3 months to 6 years) and childhood epilepsy with centrotemporal spikes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Carboxypeptidase A6 |
|---|---|
| UniProt accession | Q8N4T0 |
| Gene | CPA6 |
| Organism | Homo sapiens |
| Length | 437 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- familial temporal lobe epilepsy 5 · score 0.51
- Febrile seizure (within the age range of 3 months to 6 years) · score 0.46
- childhood epilepsy with centrotemporal spikes · score 0.45
- Rolandic epilepsy · score 0.45
- benign familial mesial temporal lobe epilepsy · score 0.37
- familial mesial temporal lobe epilepsy with febrile seizures · score 0.37
- Seizure · score 0.34
- Periventricular heterotopia · score 0.32
- Focal-onset seizure · score 0.32
- Confusion · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4T0-F1 | alphafold | PREDICTED | 90.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4T0.
Amino-acid sequence (437 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CPA6?
The strongest Open Targets associations for CPA6 are familial temporal lobe epilepsy 5, Febrile seizure (within the age range of 3 months to 6 years), childhood epilepsy with centrotemporal spikes, Rolandic epilepsy and benign familial mesial temporal lobe epilepsy.
How long is the CPA6 protein?
The Homo sapiens CPA6 protein (UniProt Q8N4T0) is 437 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4T0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4T0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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