Rho guanine nucleotide exchange factor 39 (ARHGEF39)
Homo sapiens — UniProt Q8N4T4
Data last refreshed: (UniProt release unknown)
Key facts
Rho guanine nucleotide exchange factor 39 (ARHGEF39) is a protein from Homo sapiens identified by UniProt accession Q8N4T4, 335 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q8N4T4; gene symbol ARHGEF39.
- Organism: Homo sapiens.
- Length: 335 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, urate measurement and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 39 |
|---|---|
| UniProt accession | Q8N4T4 |
| Gene | ARHGEF39 |
| Organism | Homo sapiens |
| Length | 335 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- urate measurement · score 0.18
- breast adenocarcinoma · score 0.18
- sex hormone-binding globulin measurement · score 0.11
- hepatocellular carcinoma · score 0.09
- nonpapillary renal cell carcinoma · score 0.07
- reticulocyte measurement · score 0.05
- reticulocyte count · score 0.03
- lymphocyte count · score 0.03
- cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4T4-F1 | alphafold | PREDICTED | 92.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4T4.
Amino-acid sequence (335 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGEF39?
The strongest Open Targets associations for ARHGEF39 are neurodegenerative disease, urate measurement, breast adenocarcinoma, sex hormone-binding globulin measurement and hepatocellular carcinoma.
How long is the ARHGEF39 protein?
The Homo sapiens ARHGEF39 protein (UniProt Q8N4T4) is 335 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4T4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4T4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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