3-oxoacyl-[acyl-carrier-protein] reductase (CBR4)
Homo sapiens — UniProt Q8N4T8
Data last refreshed: (UniProt release unknown)
Key facts
3-oxoacyl-[acyl-carrier-protein] reductase (CBR4) is a protein from Homo sapiens identified by UniProt accession Q8N4T8, 237 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8N4T8; gene symbol CBR4.
- Organism: Homo sapiens.
- Length: 237 amino acids.
- Top disease associations (Open Targets): protein measurement, head injury and Back pain.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 3-oxoacyl-[acyl-carrier-protein] reductase |
|---|---|
| UniProt accession | Q8N4T8 |
| Gene | CBR4 |
| Organism | Homo sapiens |
| Length | 237 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.26
- head injury · score 0.17
- Back pain · score 0.09
- systolic blood pressure · score 0.08
- forced expiratory volume · score 0.08
- refractive error measurement · score 0.07
- autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.07
- Gorham-Stout disease · score 0.07
- peak expiratory flow · score 0.07
- pulse pressure measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4T8-F1 | alphafold | PREDICTED | 96.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4T8.
Amino-acid sequence (237 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CBR4?
The strongest Open Targets associations for CBR4 are protein measurement, head injury, Back pain, systolic blood pressure and forced expiratory volume.
How long is the CBR4 protein?
The Homo sapiens CBR4 protein (UniProt Q8N4T8) is 237 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4T8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4T8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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