DnaJ homolog subfamily C member 22 (DNAJC22)
Homo sapiens — UniProt Q8N4W6
Data last refreshed: (UniProt release unknown)
Key facts
DnaJ homolog subfamily C member 22 (DNAJC22) is a protein from Homo sapiens identified by UniProt accession Q8N4W6, 341 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q8N4W6; gene symbol DNAJC22.
- Organism: Homo sapiens.
- Length: 341 amino acids.
- Top disease associations (Open Targets): visual perception measurement, smoking initiation and Barrett's esophagus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DnaJ homolog subfamily C member 22 |
|---|---|
| UniProt accession | Q8N4W6 |
| Gene | DNAJC22 |
| Organism | Homo sapiens |
| Length | 341 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- visual perception measurement · score 0.17
- smoking initiation · score 0.10
- Barrett's esophagus · score 0.07
- esophageal adenocarcinoma · score 0.05
- diet measurement · score 0.04
- diabetes mellitus · score 0.04
- non-small cell lung carcinoma · score 0.03
- alcohol consumption measurement · score 0.03
- uterine leiomyosarcoma · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4W6-F1 | alphafold | PREDICTED | 81.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4W6.
Amino-acid sequence (341 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAJC22?
The strongest Open Targets associations for DNAJC22 are visual perception measurement, smoking initiation, Barrett's esophagus, esophageal adenocarcinoma and diet measurement.
How long is the DNAJC22 protein?
The Homo sapiens DNAJC22 protein (UniProt Q8N4W6) is 341 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4W6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4W6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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