Actin filament-associated protein 1-like 2 (AFAP1L2)
Homo sapiens — UniProt Q8N4X5
Data last refreshed: (UniProt release unknown)
Key facts
Actin filament-associated protein 1-like 2 (AFAP1L2) is a protein from Homo sapiens identified by UniProt accession Q8N4X5, 818 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q8N4X5; gene symbol AFAP1L2.
- Organism: Homo sapiens.
- Length: 818 amino acids.
- Top disease associations (Open Targets): platelet component distribution width, appendicular lean mass and grip strength measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Actin filament-associated protein 1-like 2 |
|---|---|
| UniProt accession | Q8N4X5 |
| Gene | AFAP1L2 |
| Organism | Homo sapiens |
| Length | 818 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.41
- appendicular lean mass · score 0.38
- grip strength measurement · score 0.33
- body height · score 0.33
- blood phosphate measurement · score 0.28
- neurodegenerative disease · score 0.24
- mean corpuscular volume · score 0.24
- neoplasm · score 0.08
- gonorrhea · score 0.05
- von Willebrand factor measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4X5-F1 | alphafold | PREDICTED | 63.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4X5.
Amino-acid sequence (818 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AFAP1L2?
The strongest Open Targets associations for AFAP1L2 are platelet component distribution width, appendicular lean mass, grip strength measurement, body height and blood phosphate measurement.
How long is the AFAP1L2 protein?
The Homo sapiens AFAP1L2 protein (UniProt Q8N4X5) is 818 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4X5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4X5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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