EF-hand calcium-binding domain-containing protein 4A (CRACR2B)
Homo sapiens — UniProt Q8N4Y2
Data last refreshed: (UniProt release unknown)
Key facts
EF-hand calcium-binding domain-containing protein 4A (CRACR2B) is a protein from Homo sapiens identified by UniProt accession Q8N4Y2, 399 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q8N4Y2; gene symbol CRACR2B.
- Organism: Homo sapiens.
- Length: 399 amino acids.
- Top disease associations (Open Targets): pulse pressure measurement, systolic blood pressure and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 4A |
|---|---|
| UniProt accession | Q8N4Y2 |
| Gene | CRACR2B |
| Organism | Homo sapiens |
| Length | 399 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.24
- systolic blood pressure · score 0.23
- platelet count · score 0.20
- mean platelet volume · score 0.13
- BMI-adjusted waist-hip ratio · score 0.09
- BMI-adjusted waist circumference · score 0.09
- chronic obstructive pulmonary disease · score 0.09
- chronic bronchitis · score 0.09
- body mass index · score 0.09
- lean body mass · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4Y2-F1 | alphafold | PREDICTED | 76.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4Y2.
Amino-acid sequence (399 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CRACR2B?
The strongest Open Targets associations for CRACR2B are pulse pressure measurement, systolic blood pressure, platelet count, mean platelet volume and BMI-adjusted waist-hip ratio.
How long is the CRACR2B protein?
The Homo sapiens CRACR2B protein (UniProt Q8N4Y2) is 399 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4Y2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4Y2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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