F-box/LRR-repeat protein 6 (FBXL6)
Homo sapiens — UniProt Q8N531
Data last refreshed: (UniProt release unknown)
Key facts
F-box/LRR-repeat protein 6 (FBXL6) is a protein from Homo sapiens identified by UniProt accession Q8N531, 539 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q8N531; gene symbol FBXL6.
- Organism: Homo sapiens.
- Length: 539 amino acids.
- Top disease associations (Open Targets): hepatocellular carcinoma, nonpapillary renal cell carcinoma and Keloid.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/LRR-repeat protein 6 |
|---|---|
| UniProt accession | Q8N531 |
| Gene | FBXL6 |
| Organism | Homo sapiens |
| Length | 539 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.10
- nonpapillary renal cell carcinoma · score 0.07
- Keloid · score 0.07
- neoplasm · score 0.07
- gonorrhea · score 0.06
- glioblastoma · score 0.04
- cancer · score 0.02
- liver and intrahepatic bile duct neoplasm · score 0.02
- COVID-19 · score 0.01
- glioblastoma multiforme · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N531-F1 | alphafold | PREDICTED | 78.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N531.
Amino-acid sequence (539 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXL6?
The strongest Open Targets associations for FBXL6 are hepatocellular carcinoma, nonpapillary renal cell carcinoma, Keloid, neoplasm and gonorrhea.
How long is the FBXL6 protein?
The Homo sapiens FBXL6 protein (UniProt Q8N531) is 539 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N531 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N531 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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