Prolyl 3-hydroxylase OGFOD1 (OGFOD1)

About Prolyl 3-hydroxylase OGFOD1

Prolyl 3-hydroxylase OGFOD1 (OGFOD1) is a protein from Homo sapiens identified by UniProt accession Q8N543, 542 residues long. MolForge cross-references it against 1 known binders and 58 disease associations.

Target properties

Protein name	Prolyl 3-hydroxylase OGFOD1
UniProt accession	Q8N543
Gene	OGFOD1
Organism	Homo sapiens
Length	542 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
body mass index · score 0.12
Bardet-Biedl syndrome · score 0.12
retinitis pigmentosa · score 0.12
diastolic blood pressure · score 0.07
type 2 diabetes mellitus · score 0.07
cancer · score 0.06
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
body weight · score 0.05
hemoglobin D disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N543-F1	alphafold	PREDICTED	86.78	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N543.

Amino-acid sequence (542 residues)

MNGKRPAEPG PARVGKKGKK EVMAEFSDAV TEETLKKQVA EAWSRRTPFS HEVIVMDMDP FLHCVIPNFI QSQDFLEGLQ KELMNLDFHE KYNDLYKFQQ SDDLKKRREP HISTLRKILF EDFRSWLSDI SKIDLESTID MSCAKYEFTD ALLCHDDELE GRRIAFILYL VPPWDRSMGG TLDLYSIDEH FQPKQIVKSL IPSWNKLVFF EVSPVSFHQV SEVLSEEKSR LSISGWFHGP SLTRPPNYFE PPIPRSPHIP QDHEILYDWI NPTYLDMDYQ VQIQEEFEES SEILLKEFLK PEKFTKVCEA LEHGHVEWSS RGPPNKRFYE KAEESKLPEI LKECMKLFRS EALFLLLSNF TGLKLHFLAP SEEDEMNDKK EAETTDITEE GTSHSPPEPE NNQMAISNNS QQSNEQTDPE PEENETKKES SVPMCQGELR HWKTGHYTLI HDHSKAEFAL DLILYCGCEG WEPEYGGFTS YIAKGEDEEL LTVNPESNSL ALVYRDRETL KFVKHINHRS LEQKKTFPNR TGFWDFSFIY YE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards