Ceramide synthase 5 (CERS5)
Homo sapiens — UniProt Q8N5B7
Data last refreshed: (UniProt release unknown)
Key facts
Ceramide synthase 5 (CERS5) is a protein from Homo sapiens identified by UniProt accession Q8N5B7, 392 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q8N5B7; gene symbol CERS5.
- Organism: Homo sapiens.
- Length: 392 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, systolic blood pressure and hypertension.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ceramide synthase 5 |
|---|---|
| UniProt accession | Q8N5B7 |
| Gene | CERS5 |
| Organism | Homo sapiens |
| Length | 392 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.39
- systolic blood pressure · score 0.39
- hypertension · score 0.34
- lymphocyte count · score 0.32
- schizophrenia · score 0.28
- blood pressure · score 0.24
- myeloid white cell count · score 0.23
- heel bone mineral density · score 0.21
- cardiovascular disease · score 0.21
- BMI-adjusted hip circumference · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5B7-F1 | alphafold | PREDICTED | 84.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5B7.
Amino-acid sequence (392 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CERS5?
The strongest Open Targets associations for CERS5 are diastolic blood pressure, systolic blood pressure, hypertension, lymphocyte count and schizophrenia.
How long is the CERS5 protein?
The Homo sapiens CERS5 protein (UniProt Q8N5B7) is 392 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5B7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5B7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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