Calcium homeostasis modulator protein 5 (CALHM5)
Homo sapiens — UniProt Q8N5C1
Data last refreshed: (UniProt release unknown)
Key facts
Calcium homeostasis modulator protein 5 (CALHM5) is a protein from Homo sapiens identified by UniProt accession Q8N5C1, 309 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q8N5C1; gene symbol CALHM5.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Top disease associations (Open Targets): sitting height measurement, esophageal squamous cell carcinoma and esophageal adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium homeostasis modulator protein 5 |
|---|---|
| UniProt accession | Q8N5C1 |
| Gene | CALHM5 |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- sitting height measurement · score 0.10
- esophageal squamous cell carcinoma · score 0.03
- esophageal adenocarcinoma · score 0.03
- blood protein measurement · score 0.03
- Barrett's esophagus · score 0.03
- body height · score 0.02
- ulcerative colitis · score 0.02
- spinal stenosis · score 0.02
- rosacea · score 0.01
- breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5C1-F1 | alphafold | PREDICTED | 90.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5C1.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CALHM5?
The strongest Open Targets associations for CALHM5 are sitting height measurement, esophageal squamous cell carcinoma, esophageal adenocarcinoma, blood protein measurement and Barrett's esophagus.
How long is the CALHM5 protein?
The Homo sapiens CALHM5 protein (UniProt Q8N5C1) is 309 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5C1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5C1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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