tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)
Homo sapiens — UniProt Q8N5C7
Data last refreshed: (UniProt release unknown)
Key facts
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1) is a protein from Homo sapiens identified by UniProt accession Q8N5C7, 304 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q8N5C7; gene symbol DTWD1.
- Organism: Homo sapiens.
- Length: 304 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, aspartate aminotransferase measurement and serum alanine aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA-uridine aminocarboxypropyltransferase 1 |
|---|---|
| UniProt accession | Q8N5C7 |
| Gene | DTWD1 |
| Organism | Homo sapiens |
| Length | 304 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- aspartate aminotransferase measurement · score 0.10
- serum alanine aminotransferase measurement · score 0.10
- FEV/FVC ratio · score 0.10
- chronic periodontitis · score 0.09
- fibroblast growth factor 7 measurement · score 0.09
- human papilloma virus infection · score 0.09
- oral cavity cancer · score 0.09
- chronic obstructive pulmonary disease · score 0.09
- forced expiratory volume · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5C7-F1 | alphafold | PREDICTED | 80.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5C7.
Amino-acid sequence (304 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DTWD1?
The strongest Open Targets associations for DTWD1 are neurodegenerative disease, aspartate aminotransferase measurement, serum alanine aminotransferase measurement, FEV/FVC ratio and chronic periodontitis.
How long is the DTWD1 protein?
The Homo sapiens DTWD1 protein (UniProt Q8N5C7) is 304 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5C7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5C7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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