TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3)
Homo sapiens — UniProt Q8N5C8
Data last refreshed: (UniProt release unknown)
Key facts
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3) is a protein from Homo sapiens identified by UniProt accession Q8N5C8, 712 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q8N5C8; gene symbol TAB3.
- Organism: Homo sapiens.
- Length: 712 amino acids.
- Top disease associations (Open Targets): COVID-19, pancreatic adenocarcinoma and thyroid gland adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
|---|---|
| UniProt accession | Q8N5C8 |
| Gene | TAB3 |
| Organism | Homo sapiens |
| Length | 712 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- pancreatic adenocarcinoma · score 0.26
- thyroid gland adenocarcinoma · score 0.26
- lung adenocarcinoma · score 0.17
- breast adenocarcinoma · score 0.14
- triple-negative breast cancer · score 0.08
- hepatocellular carcinoma · score 0.08
- esophageal squamous cell carcinoma · score 0.03
- blood protein measurement · score 0.02
- non-small cell lung carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5C8-F1 | alphafold | PREDICTED | 53.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5C8.
Amino-acid sequence (712 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TAB3?
The strongest Open Targets associations for TAB3 are COVID-19, pancreatic adenocarcinoma, thyroid gland adenocarcinoma, lung adenocarcinoma and breast adenocarcinoma.
How long is the TAB3 protein?
The Homo sapiens TAB3 protein (UniProt Q8N5C8) is 712 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5C8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5C8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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