WD and tetratricopeptide repeats protein 1 (WDTC1)
Homo sapiens — UniProt Q8N5D0
Data last refreshed: (UniProt release unknown)
Key facts
WD and tetratricopeptide repeats protein 1 (WDTC1) is a protein from Homo sapiens identified by UniProt accession Q8N5D0, 677 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.
- UniProt accession: Q8N5D0; gene symbol WDTC1.
- Organism: Homo sapiens.
- Length: 677 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, MODY and hyperinsulinism due to INSR deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WD and tetratricopeptide repeats protein 1 |
|---|---|
| UniProt accession | Q8N5D0 |
| Gene | WDTC1 |
| Organism | Homo sapiens |
| Length | 677 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (119)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- MODY · score 0.07
- hyperinsulinism due to INSR deficiency · score 0.07
- obesity due to melanocortin 4 receptor deficiency · score 0.06
- lipoprotein A measurement · score 0.06
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.06
- hyperinsulinism due to glucokinase deficiency · score 0.06
- short stature due to primary acid-labile subunit deficiency · score 0.05
- type 2 diabetes mellitus · score 0.05
- hyperinsulinemic hypoglycemia, familial, 1 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5D0-F1 | alphafold | PREDICTED | 81.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5D0.
Amino-acid sequence (677 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WDTC1?
The strongest Open Targets associations for WDTC1 are neurodegenerative disease, MODY, hyperinsulinism due to INSR deficiency, obesity due to melanocortin 4 receptor deficiency and lipoprotein A measurement.
How long is the WDTC1 protein?
The Homo sapiens WDTC1 protein (UniProt Q8N5D0) is 677 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5D0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5D0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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