Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (GBGT1)
Homo sapiens — UniProt Q8N5D6
Data last refreshed: (UniProt release unknown)
Key facts
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (GBGT1) is a protein from Homo sapiens identified by UniProt accession Q8N5D6, 347 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q8N5D6; gene symbol GBGT1.
- Organism: Homo sapiens.
- Length: 347 amino acids.
- Top disease associations (Open Targets): alkaline phosphatase measurement, neurodegenerative disease and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 |
|---|---|
| UniProt accession | Q8N5D6 |
| Gene | GBGT1 |
| Organism | Homo sapiens |
| Length | 347 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.53
- neurodegenerative disease · score 0.39
- platelet component distribution width · score 0.24
- platelet count · score 0.23
- blood protein measurement · score 0.14
- sum of eosinophil and basophil counts · score 0.10
- angiopoietin-1 receptor measurement · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.06
- 46,XX testicular disorder of sex development · score 0.05
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5D6-F1 | alphafold | PREDICTED | 86.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5D6.
Amino-acid sequence (347 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GBGT1?
The strongest Open Targets associations for GBGT1 are alkaline phosphatase measurement, neurodegenerative disease, platelet component distribution width, platelet count and blood protein measurement.
How long is the GBGT1 protein?
The Homo sapiens GBGT1 protein (UniProt Q8N5D6) is 347 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5D6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5D6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.