NF-kappa-B-activating protein (NKAP)

About NF-kappa-B-activating protein

NF-kappa-B-activating protein (NKAP) is a protein from Homo sapiens identified by UniProt accession Q8N5F7, 415 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	NF-kappa-B-activating protein
UniProt accession	Q8N5F7
Gene	NKAP
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

intellectual developmental disorder, X-linked, syndromic, Hackmann-Di Donato type · score 0.71
Global developmental delay · score 0.40
Intellectual disability · score 0.37
genetic disorder · score 0.18
developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy · score 0.12
congenital heart disease · score 0.07
glioblastoma · score 0.06
neoplasm · score 0.04
hepatocellular carcinoma · score 0.03
cancer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N5F7-F1	alphafold	PREDICTED	61.51	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5F7.

Amino-acid sequence (415 residues)

MAPVSGSRSP DREASGSGGR RRSSSKSPKP SKSARSPRGR RSRSHSCSRS GDRNGLTHQL GGLSQGSRNQ SYRSRSRSRS RERPSAPRGI PFASASSSVY YGSYSRPYGS DKPWPSLLDK EREESLRQKR LSERERIGEL GAPEVWGLSP KNPEPDSDEH TPVEDEEPKK STTSASTSEE EKKKKSSRSK ERSKKRRKKK SSKRKHKKYS EDSDSDSDSE TDSSDEDNKR RAKKAKKKEK KKKHRSKKYK KKRSKKSRKE SSDSSSKESQ EEFLENPWKD RTKAEEPSDL IGPEAPKTLT SQDDKPLNYG HALLPGEGAA MAEYVKAGKR IPRRGEIGLT SEEIASFECS GYVMSGSRHR RMEAVRLRKE NQIYSADEKR ALASFNQEER RKRENKILAS FREMVYRKTK GKDDK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards