Leucine repeat adapter protein 25 (FAM89B)
Homo sapiens — UniProt Q8N5H3
Data last refreshed: (UniProt release unknown)
Key facts
Leucine repeat adapter protein 25 (FAM89B) is a protein from Homo sapiens identified by UniProt accession Q8N5H3, 189 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q8N5H3; gene symbol FAM89B.
- Organism: Homo sapiens.
- Length: 189 amino acids.
- Top disease associations (Open Targets): FEV/FVC ratio, electrocardiography and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine repeat adapter protein 25 |
|---|---|
| UniProt accession | Q8N5H3 |
| Gene | FAM89B |
| Organism | Homo sapiens |
| Length | 189 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.14
- electrocardiography · score 0.05
- self reported educational attainment · score 0.05
- Red cell distribution width · score 0.05
- body height · score 0.04
- type 2 diabetes mellitus · score 0.04
- osteoarthritis, hip · score 0.04
- alkaline phosphatase measurement · score 0.04
- refractive error measurement · score 0.04
- angina pectoris · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5H3-F1 | alphafold | PREDICTED | 68.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5H3.
Amino-acid sequence (189 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM89B?
The strongest Open Targets associations for FAM89B are FEV/FVC ratio, electrocardiography, self reported educational attainment, Red cell distribution width and body height.
How long is the FAM89B protein?
The Homo sapiens FAM89B protein (UniProt Q8N5H3) is 189 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5H3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5H3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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