SH2 domain-containing protein 3C (SH2D3C)
Homo sapiens — UniProt Q8N5H7
Data last refreshed: (UniProt release unknown)
Key facts
SH2 domain-containing protein 3C (SH2D3C) is a protein from Homo sapiens identified by UniProt accession Q8N5H7, 860 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.
- UniProt accession: Q8N5H7; gene symbol SH2D3C.
- Organism: Homo sapiens.
- Length: 860 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, monocyte count and monocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2 domain-containing protein 3C |
|---|---|
| UniProt accession | Q8N5H7 |
| Gene | SH2D3C |
| Organism | Homo sapiens |
| Length | 860 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (184)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- monocyte count · score 0.34
- monocyte percentage of leukocytes · score 0.31
- neutrophil percentage of leukocytes · score 0.30
- granulocyte percentage of myeloid white cells · score 0.25
- blood protein measurement · score 0.23
- basophil percentage of leukocytes · score 0.23
- eosinophil percentage of leukocytes · score 0.23
- reticulocyte measurement · score 0.20
- basophil count · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5H7-F1 | alphafold | PREDICTED | 66.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5H7.
Amino-acid sequence (860 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH2D3C?
The strongest Open Targets associations for SH2D3C are neurodegenerative disease, monocyte count, monocyte percentage of leukocytes, neutrophil percentage of leukocytes and granulocyte percentage of myeloid white cells.
How long is the SH2D3C protein?
The Homo sapiens SH2D3C protein (UniProt Q8N5H7) is 860 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5H7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5H7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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