Arrestin domain-containing protein 1 (ARRDC1)
Homo sapiens — UniProt Q8N5I2
Data last refreshed: (UniProt release unknown)
Key facts
Arrestin domain-containing protein 1 (ARRDC1) is a protein from Homo sapiens identified by UniProt accession Q8N5I2, 433 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q8N5I2; gene symbol ARRDC1.
- Organism: Homo sapiens.
- Length: 433 amino acids.
- Top disease associations (Open Targets): Eczematoid dermatitis, atopic eczema and asthma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Arrestin domain-containing protein 1 |
|---|---|
| UniProt accession | Q8N5I2 |
| Gene | ARRDC1 |
| Organism | Homo sapiens |
| Length | 433 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- Eczematoid dermatitis · score 0.30
- atopic eczema · score 0.29
- asthma · score 0.28
- childhood onset asthma · score 0.27
- atopic asthma · score 0.22
- dermatitis · score 0.21
- lower respiratory tract disease · score 0.15
- breast cancer · score 0.07
- age-related macular degeneration · score 0.07
- hepatocellular carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5I2-F1 | alphafold | PREDICTED | 77.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5I2.
Amino-acid sequence (433 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARRDC1?
The strongest Open Targets associations for ARRDC1 are Eczematoid dermatitis, atopic eczema, asthma, childhood onset asthma and atopic asthma.
How long is the ARRDC1 protein?
The Homo sapiens ARRDC1 protein (UniProt Q8N5I2) is 433 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5I2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5I2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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