Polyprenol dehydrogenase (DHRSX)
Homo sapiens — UniProt Q8N5I4
Data last refreshed: (UniProt release unknown)
Key facts
Polyprenol dehydrogenase (DHRSX) is a protein from Homo sapiens identified by UniProt accession Q8N5I4, 330 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q8N5I4; gene symbol DHRSX.
- Organism: Homo sapiens.
- Length: 330 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hepatocellular carcinoma and precursor B-cell acute lymphoblastic leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polyprenol dehydrogenase |
|---|---|
| UniProt accession | Q8N5I4 |
| Gene | DHRSX |
| Organism | Homo sapiens |
| Length | 330 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- hepatocellular carcinoma · score 0.17
- precursor B-cell acute lymphoblastic leukemia · score 0.01
- Timothy syndrome · score 0.00
- muscular dystrophy · score 0.00
- Muscular dystrophy · score 0.00
- Parkinson disease · score 0.00
- acute lymphoblastic leukemia · score 0.00
- pancreatic ductal adenocarcinoma · score 0.00
- Infertility · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5I4-F1 | alphafold | PREDICTED | 94.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5I4.
Amino-acid sequence (330 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DHRSX?
The strongest Open Targets associations for DHRSX are neurodegenerative disease, hepatocellular carcinoma, precursor B-cell acute lymphoblastic leukemia, Timothy syndrome and muscular dystrophy.
How long is the DHRSX protein?
The Homo sapiens DHRSX protein (UniProt Q8N5I4) is 330 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5I4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5I4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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