Transcription factor Spi-C (SPIC)
Homo sapiens — UniProt Q8N5J4
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor Spi-C (SPIC) is a protein from Homo sapiens identified by UniProt accession Q8N5J4, 248 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8N5J4; gene symbol SPIC.
- Organism: Homo sapiens.
- Length: 248 amino acids.
- Top disease associations (Open Targets): lymphocyte count, leukocyte count and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor Spi-C |
|---|---|
| UniProt accession | Q8N5J4 |
| Gene | SPIC |
| Organism | Homo sapiens |
| Length | 248 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.48
- leukocyte count · score 0.45
- reticulocyte count · score 0.44
- monocyte count · score 0.39
- high density lipoprotein cholesterol measurement · score 0.39
- myeloid white cell count · score 0.38
- reticulocyte measurement · score 0.38
- platelet component distribution width · score 0.38
- neutrophil count · score 0.38
- platelet count · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5J4-F1 | alphafold | PREDICTED | 67.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5J4.
Amino-acid sequence (248 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPIC?
The strongest Open Targets associations for SPIC are lymphocyte count, leukocyte count, reticulocyte count, monocyte count and high density lipoprotein cholesterol measurement.
How long is the SPIC protein?
The Homo sapiens SPIC protein (UniProt Q8N5J4) is 248 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5J4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5J4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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