CDGSH iron-sulfur domain-containing protein 2 (CISD2)
Homo sapiens — UniProt Q8N5K1
Data last refreshed: (UniProt release unknown)
Key facts
CDGSH iron-sulfur domain-containing protein 2 (CISD2) is a protein from Homo sapiens identified by UniProt accession Q8N5K1, 135 residues long. MolForge cross-references it against 2 known binders and 192 disease associations.
- UniProt accession: Q8N5K1; gene symbol CISD2.
- Organism: Homo sapiens.
- Length: 135 amino acids.
- Top disease associations (Open Targets): Wolfram syndrome, hearing loss and refractive error measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CDGSH iron-sulfur domain-containing protein 2 |
|---|---|
| UniProt accession | Q8N5K1 |
| Gene | CISD2 |
| Organism | Homo sapiens |
| Length | 135 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (192)
Diseases linked to this target (Open Targets).
- Wolfram syndrome · score 0.74
- hearing loss · score 0.37
- refractive error measurement · score 0.19
- glomerular filtration rate · score 0.16
- genetic disorder · score 0.15
- serum alanine aminotransferase measurement · score 0.15
- schizophrenia · score 0.15
- sarcoidosis · score 0.14
- fasting blood glucose measurement · score 0.14
- creatinine measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5K1-F1 | alphafold | PREDICTED | 90.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5K1.
Amino-acid sequence (135 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CISD2?
The strongest Open Targets associations for CISD2 are Wolfram syndrome, hearing loss, refractive error measurement, glomerular filtration rate and genetic disorder.
How long is the CISD2 protein?
The Homo sapiens CISD2 protein (UniProt Q8N5K1) is 135 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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