ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2)
Homo sapiens — UniProt Q8N5M1
Data last refreshed: (UniProt release unknown)
Key facts
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) is a protein from Homo sapiens identified by UniProt accession Q8N5M1, 289 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8N5M1; gene symbol ATPAF2.
- Organism: Homo sapiens.
- Length: 289 amino acids.
- Top disease associations (Open Targets): mitochondrial complex V (ATP synthase) deficiency, nuclear type 1, Isolated ATP synthase deficiency and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP synthase mitochondrial F1 complex assembly factor 2 |
|---|---|
| UniProt accession | Q8N5M1 |
| Gene | ATPAF2 |
| Organism | Homo sapiens |
| Length | 289 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- mitochondrial complex V (ATP synthase) deficiency, nuclear type 1 · score 0.66
- Isolated ATP synthase deficiency · score 0.58
- schizophrenia · score 0.25
- BMI-adjusted waist-hip ratio · score 0.20
- autism spectrum disorder · score 0.17
- attention deficit hyperactivity disorder · score 0.16
- systolic blood pressure · score 0.16
- Tourette syndrome · score 0.16
- unipolar depression · score 0.16
- obsessive-compulsive disorder · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5M1-F1 | alphafold | PREDICTED | 85.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5M1.
Amino-acid sequence (289 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATPAF2?
The strongest Open Targets associations for ATPAF2 are mitochondrial complex V (ATP synthase) deficiency, nuclear type 1, Isolated ATP synthase deficiency, schizophrenia, BMI-adjusted waist-hip ratio and autism spectrum disorder.
How long is the ATPAF2 protein?
The Homo sapiens ATPAF2 protein (UniProt Q8N5M1) is 289 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5M1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5M1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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