Protein jagunal homolog 1 (JAGN1)
Homo sapiens — UniProt Q8N5M9
Data last refreshed: (UniProt release unknown)
Key facts
Protein jagunal homolog 1 (JAGN1) is a protein from Homo sapiens identified by UniProt accession Q8N5M9, 183 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q8N5M9; gene symbol JAGN1.
- Organism: Homo sapiens.
- Length: 183 amino acids.
- Top disease associations (Open Targets): autosomal recessive severe congenital neutropenia due to JAGN1 deficiency, severe congenital neutropenia and constitutional neutropenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein jagunal homolog 1 |
|---|---|
| UniProt accession | Q8N5M9 |
| Gene | JAGN1 |
| Organism | Homo sapiens |
| Length | 183 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- autosomal recessive severe congenital neutropenia due to JAGN1 deficiency · score 0.75
- severe congenital neutropenia · score 0.72
- constitutional neutropenia · score 0.47
- neurodegenerative disease · score 0.29
- genetic disorder · score 0.18
- sphingomyelin measurement · score 0.07
- acute myeloid leukemia · score 0.01
- myelodysplastic syndrome · score 0.01
- neutropenia · score 0.01
- rubella · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5M9-F1 | alphafold | PREDICTED | 91.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5M9.
Amino-acid sequence (183 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with JAGN1?
The strongest Open Targets associations for JAGN1 are autosomal recessive severe congenital neutropenia due to JAGN1 deficiency, severe congenital neutropenia, constitutional neutropenia, neurodegenerative disease and genetic disorder.
How long is the JAGN1 protein?
The Homo sapiens JAGN1 protein (UniProt Q8N5M9) is 183 amino acids long.
Browse: Targets: J · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5M9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5M9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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