Zinc finger CCCH domain-containing protein 8 (ZC3H8)
Homo sapiens — UniProt Q8N5P1
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger CCCH domain-containing protein 8 (ZC3H8) is a protein from Homo sapiens identified by UniProt accession Q8N5P1, 291 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q8N5P1; gene symbol ZC3H8.
- Organism: Homo sapiens.
- Length: 291 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, multiple sclerosis and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger CCCH domain-containing protein 8 |
|---|---|
| UniProt accession | Q8N5P1 |
| Gene | ZC3H8 |
| Organism | Homo sapiens |
| Length | 291 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- multiple sclerosis · score 0.37
- Parkinson disease · score 0.37
- lysosomal storage disease · score 0.37
- Alzheimer disease · score 0.37
- aspartate aminotransferase measurement · score 0.14
- spinal fracture · score 0.11
- age at first facial hair · score 0.10
- brain measurement · score 0.09
- cortical thickness · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5P1-F1 | alphafold | PREDICTED | 67.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5P1.
Amino-acid sequence (291 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZC3H8?
The strongest Open Targets associations for ZC3H8 are neurodegenerative disease, multiple sclerosis, Parkinson disease, lysosomal storage disease and Alzheimer disease.
How long is the ZC3H8 protein?
The Homo sapiens ZC3H8 protein (UniProt Q8N5P1) is 291 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5P1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5P1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.