Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1)
Homo sapiens — UniProt Q8N5S9
Data last refreshed: (UniProt release unknown)
Key facts
Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) is a protein from Homo sapiens identified by UniProt accession Q8N5S9, 505 residues long. MolForge cross-references it against 7 known binders and 36 disease associations.
- UniProt accession: Q8N5S9; gene symbol CAMKK1.
- Organism: Homo sapiens.
- Length: 505 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lung adenocarcinoma and Monoamine oxidase A deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium/calmodulin-dependent protein kinase kinase 1 |
|---|---|
| UniProt accession | Q8N5S9 |
| Gene | CAMKK1 |
| Organism | Homo sapiens |
| Length | 505 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- lung adenocarcinoma · score 0.18
- Monoamine oxidase A deficiency · score 0.06
- acute myocardial infarction · score 0.03
- glioblastoma multiforme · score 0.02
- Hepatic steatosis · score 0.02
- platelet count · score 0.02
- laryngotracheoesophageal cleft · score 0.02
- mean platelet volume · score 0.02
- cardiovascular disease · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5S9-F1 | alphafold | PREDICTED | 71.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5S9.
Amino-acid sequence (505 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CAMKK1?
The strongest Open Targets associations for CAMKK1 are neurodegenerative disease, lung adenocarcinoma, Monoamine oxidase A deficiency, acute myocardial infarction and glioblastoma multiforme.
How long is the CAMKK1 protein?
The Homo sapiens CAMKK1 protein (UniProt Q8N5S9) is 505 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5S9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5S9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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