TBC1 domain family member 19 (TBC1D19)
Homo sapiens — UniProt Q8N5T2
Data last refreshed: (UniProt release unknown)
Key facts
TBC1 domain family member 19 (TBC1D19) is a protein from Homo sapiens identified by UniProt accession Q8N5T2, 526 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q8N5T2; gene symbol TBC1D19.
- Organism: Homo sapiens.
- Length: 526 amino acids.
- Top disease associations (Open Targets): cardiovascular disease, hypertension and blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TBC1 domain family member 19 |
|---|---|
| UniProt accession | Q8N5T2 |
| Gene | TBC1D19 |
| Organism | Homo sapiens |
| Length | 526 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.36
- hypertension · score 0.32
- blood pressure · score 0.12
- diastolic blood pressure · score 0.11
- systolic blood pressure · score 0.11
- Agents acting on the renin-angiotensin system use measurement · score 0.10
- essential hypertension · score 0.09
- mean arterial pressure · score 0.08
- Calcium channel blocker use measurement · score 0.05
- Inguinal hernia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5T2-F1 | alphafold | PREDICTED | 91.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5T2.
Amino-acid sequence (526 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBC1D19?
The strongest Open Targets associations for TBC1D19 are cardiovascular disease, hypertension, blood pressure, diastolic blood pressure and systolic blood pressure.
How long is the TBC1D19 protein?
The Homo sapiens TBC1D19 protein (UniProt Q8N5T2) is 526 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5T2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5T2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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