Ephexin-1 (NGEF)
Homo sapiens — UniProt Q8N5V2
Data last refreshed: (UniProt release unknown)
Key facts
Ephexin-1 (NGEF) is a protein from Homo sapiens identified by UniProt accession Q8N5V2, 710 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q8N5V2; gene symbol NGEF.
- Organism: Homo sapiens.
- Length: 710 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, schizophrenia and bipolar disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ephexin-1 |
|---|---|
| UniProt accession | Q8N5V2 |
| Gene | NGEF |
| Organism | Homo sapiens |
| Length | 710 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.43
- schizophrenia · score 0.43
- bipolar disorder · score 0.41
- sitting height measurement · score 0.38
- gut microbiome measurement · score 0.37
- bone quantitative ultrasound measurement · score 0.34
- Tourette syndrome · score 0.34
- mathematical ability · score 0.30
- autism spectrum disorder · score 0.30
- attention deficit hyperactivity disorder · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5V2-F1 | alphafold | PREDICTED | 71.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5V2.
Amino-acid sequence (710 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NGEF?
The strongest Open Targets associations for NGEF are heel bone mineral density, schizophrenia, bipolar disorder, sitting height measurement and gut microbiome measurement.
How long is the NGEF protein?
The Homo sapiens NGEF protein (UniProt Q8N5V2) is 710 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5V2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5V2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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