Refilin-B (RFLNB)
Homo sapiens — UniProt Q8N5W9
Data last refreshed: (UniProt release unknown)
Key facts
Refilin-B (RFLNB) is a protein from Homo sapiens identified by UniProt accession Q8N5W9, 214 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q8N5W9; gene symbol RFLNB.
- Organism: Homo sapiens.
- Length: 214 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist circumference, sitting height measurement and BMI-adjusted hip circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Refilin-B |
|---|---|
| UniProt accession | Q8N5W9 |
| Gene | RFLNB |
| Organism | Homo sapiens |
| Length | 214 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist circumference · score 0.22
- sitting height measurement · score 0.17
- BMI-adjusted hip circumference · score 0.17
- physical activity measurement · score 0.12
- appendicular lean mass · score 0.09
- high density lipoprotein cholesterol measurement · score 0.05
- type 2 diabetes mellitus · score 0.04
- drug use measurement · score 0.02
- neoplasm · score 0.02
- ovarian carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5W9-F1 | alphafold | PREDICTED | 53.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5W9.
Amino-acid sequence (214 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RFLNB?
The strongest Open Targets associations for RFLNB are BMI-adjusted waist circumference, sitting height measurement, BMI-adjusted hip circumference, physical activity measurement and appendicular lean mass.
How long is the RFLNB protein?
The Homo sapiens RFLNB protein (UniProt Q8N5W9) is 214 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5W9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5W9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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