Eukaryotic translation initiation factor 4E type 3 (EIF4E3)
Homo sapiens — UniProt Q8N5X7
Data last refreshed: (UniProt release unknown)
Key facts
Eukaryotic translation initiation factor 4E type 3 (EIF4E3) is a protein from Homo sapiens identified by UniProt accession Q8N5X7, 224 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.
- UniProt accession: Q8N5X7; gene symbol EIF4E3.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): eosinophil count, monocyte count and monocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Eukaryotic translation initiation factor 4E type 3 |
|---|---|
| UniProt accession | Q8N5X7 |
| Gene | EIF4E3 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (101)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.47
- monocyte count · score 0.44
- monocyte percentage of leukocytes · score 0.43
- serum albumin measurement · score 0.40
- mosaic loss of chromosome Y measurement · score 0.39
- apolipoprotein A 1 measurement · score 0.38
- hair shape measurement · score 0.36
- neuroticism measurement · score 0.32
- mitochondrial DNA measurement · score 0.31
- balding measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5X7-F1 | alphafold | PREDICTED | 78.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5X7.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EIF4E3?
The strongest Open Targets associations for EIF4E3 are eosinophil count, monocyte count, monocyte percentage of leukocytes, serum albumin measurement and mosaic loss of chromosome Y measurement.
How long is the EIF4E3 protein?
The Homo sapiens EIF4E3 protein (UniProt Q8N5X7) is 224 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5X7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5X7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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