Protein mono-ADP-ribosyltransferase PARP16 (PARP16)
Homo sapiens — UniProt Q8N5Y8
Data last refreshed: (UniProt release unknown)
Key facts
Protein mono-ADP-ribosyltransferase PARP16 (PARP16) is a protein from Homo sapiens identified by UniProt accession Q8N5Y8, 322 residues long. MolForge cross-references it against 4 known binders and 17 disease associations.
- UniProt accession: Q8N5Y8; gene symbol PARP16.
- Organism: Homo sapiens.
- Length: 322 amino acids.
- Top disease associations (Open Targets): COVID-19, severe acute respiratory syndrome and cardiac hypertrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase PARP16 |
|---|---|
| UniProt accession | Q8N5Y8 |
| Gene | PARP16 |
| Organism | Homo sapiens |
| Length | 322 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- cardiac hypertrophy · score 0.07
- protein measurement · score 0.03
- cancer · score 0.02
- persistent truncus arteriosus · score 0.02
- Mental deterioration · score 0.01
- infect · score 0.01
- infection · score 0.01
- Cerebral ischemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5Y8-F1 | alphafold | PREDICTED | 88.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5Y8.
Amino-acid sequence (322 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PARP16?
The strongest Open Targets associations for PARP16 are COVID-19, severe acute respiratory syndrome, cardiac hypertrophy, protein measurement and cancer.
How long is the PARP16 protein?
The Homo sapiens PARP16 protein (UniProt Q8N5Y8) is 322 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5Y8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5Y8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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