Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT)
Homo sapiens — UniProt Q8N5Z0
Data last refreshed: (UniProt release unknown)
Key facts
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT) is a protein from Homo sapiens identified by UniProt accession Q8N5Z0, 425 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q8N5Z0; gene symbol AADAT.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, lean body mass and alcohol consumption measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
|---|---|
| UniProt accession | Q8N5Z0 |
| Gene | AADAT |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.46
- lean body mass · score 0.40
- alcohol consumption measurement · score 0.39
- thyroxine measurement · score 0.36
- fat body mass · score 0.35
- chronotype measurement · score 0.30
- hormone measurement · score 0.30
- body weight · score 0.29
- body height · score 0.24
- protein measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N5Z0-F1 | alphafold | PREDICTED | 97.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N5Z0.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AADAT?
The strongest Open Targets associations for AADAT are sex hormone-binding globulin measurement, lean body mass, alcohol consumption measurement, thyroxine measurement and fat body mass.
How long is the AADAT protein?
The Homo sapiens AADAT protein (UniProt Q8N5Z0) is 425 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N5Z0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N5Z0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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