Immunoglobulin superfamily member 1 (IGSF1)
Homo sapiens — UniProt Q8N6C5
Data last refreshed: (UniProt release unknown)
Key facts
Immunoglobulin superfamily member 1 (IGSF1) is a protein from Homo sapiens identified by UniProt accession Q8N6C5, 1336 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q8N6C5; gene symbol IGSF1.
- Organism: Homo sapiens.
- Length: 1336 amino acids.
- Top disease associations (Open Targets): X-linked central congenital hypothyroidism with late-onset testicular enlargement, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Immunoglobulin superfamily member 1 |
|---|---|
| UniProt accession | Q8N6C5 |
| Gene | IGSF1 |
| Organism | Homo sapiens |
| Length | 1336 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- X-linked central congenital hypothyroidism with late-onset testicular enlargement · score 0.76
- neurodegenerative disease · score 0.52
- genetic disorder · score 0.41
- central congenital hypothyroidism · score 0.38
- hyperthyroxinemia · score 0.06
- thyroid hormone metabolism, abnormal 1 · score 0.06
- thyroid hormone metabolism, abnormal, 3 · score 0.05
- pituitary hormone deficiency, combined or isolated, 8 · score 0.05
- Non-acquired isolated growth hormone deficiency · score 0.05
- selective pituitary resistance to thyroid hormone · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6C5-F1 | alphafold | PREDICTED | 73.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6C5.
Amino-acid sequence (1336 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IGSF1?
The strongest Open Targets associations for IGSF1 are X-linked central congenital hypothyroidism with late-onset testicular enlargement, neurodegenerative disease, genetic disorder, central congenital hypothyroidism and hyperthyroxinemia.
How long is the IGSF1 protein?
The Homo sapiens IGSF1 protein (UniProt Q8N6C5) is 1336 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6C5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6C5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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