E3 ubiquitin-protein ligase RNF182 (RNF182)

About E3 ubiquitin-protein ligase RNF182

E3 ubiquitin-protein ligase RNF182 (RNF182) is a protein from Homo sapiens identified by UniProt accession Q8N6D2, 247 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF182
UniProt accession	Q8N6D2
Gene	RNF182
Organism	Homo sapiens
Length	247 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

hematocrit · score 0.38
mean corpuscular hemoglobin concentration · score 0.37
Red cell distribution width · score 0.35
self reported educational attainment · score 0.30
mean corpuscular volume · score 0.30
intelligence · score 0.20
1,5 anhydroglucitol measurement · score 0.17
cataract · score 0.09
lung adenocarcinoma · score 0.09
non-small cell lung carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N6D2-F1	alphafold	PREDICTED	70.27	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6D2.

Amino-acid sequence (247 residues)

MASQPPEDTA ESQASDELEC KICYNRYNLK QRKPKVLECC HRVCAKCLYK IIDFGDSPQG VIVCPFCRFE TCLPDDEVSS LPDDNNILVN LTCGGKGKKC LPENPTELLL TPKRLASLVS PSHTSSNCLV ITIMEVQRES SPSLSSTPVV EFYRPASFDS VTTVSHNWTV WNCTSLLFQT SIRVLVWLLG LLYFSSLPLG IYLLVSKKVT LGVVFVSLVP SSLVILMVYG FCQCVCHEFL DCMAPPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards