Claudin-19 (CLDN19)
Homo sapiens — UniProt Q8N6F1
Data last refreshed: (UniProt release unknown)
Key facts
Claudin-19 (CLDN19) is a protein from Homo sapiens identified by UniProt accession Q8N6F1, 224 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q8N6F1; gene symbol CLDN19.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): renal hypomagnesemia 5 with ocular involvement, nephrocalcinosis and nephrolithiasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Claudin-19 |
|---|---|
| UniProt accession | Q8N6F1 |
| Gene | CLDN19 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- renal hypomagnesemia 5 with ocular involvement · score 0.81
- nephrocalcinosis · score 0.26
- nephrolithiasis · score 0.26
- breast adenocarcinoma · score 0.25
- genetic disorder · score 0.18
- glioblastoma multiforme · score 0.16
- gastric adenocarcinoma · score 0.09
- hypertrophic cardiomyopathy · score 0.06
- Brugada syndrome · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6F1-F1 | alphafold | PREDICTED | 80.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6F1.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLDN19?
The strongest Open Targets associations for CLDN19 are renal hypomagnesemia 5 with ocular involvement, nephrocalcinosis, nephrolithiasis, breast adenocarcinoma and genetic disorder.
How long is the CLDN19 protein?
The Homo sapiens CLDN19 protein (UniProt Q8N6F1) is 224 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6F1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6F1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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