Methyltransferase-like protein 27 (METTL27)
Homo sapiens — UniProt Q8N6F8
Data last refreshed: (UniProt release unknown)
Key facts
Methyltransferase-like protein 27 (METTL27) is a protein from Homo sapiens identified by UniProt accession Q8N6F8, 245 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q8N6F8; gene symbol METTL27.
- Organism: Homo sapiens.
- Length: 245 amino acids.
- Top disease associations (Open Targets): serum alanine aminotransferase measurement, asthma and balding measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Methyltransferase-like protein 27 |
|---|---|
| UniProt accession | Q8N6F8 |
| Gene | METTL27 |
| Organism | Homo sapiens |
| Length | 245 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.26
- asthma · score 0.21
- balding measurement · score 0.18
- body height · score 0.14
- pulse pressure measurement · score 0.11
- hemorrhoid · score 0.07
- platelet component distribution width · score 0.06
- mean platelet volume · score 0.04
- BMI-adjusted waist circumference · score 0.03
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6F8-F1 | alphafold | PREDICTED | 83.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6F8.
Amino-acid sequence (245 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL27?
The strongest Open Targets associations for METTL27 are serum alanine aminotransferase measurement, asthma, balding measurement, body height and pulse pressure measurement.
How long is the METTL27 protein?
The Homo sapiens METTL27 protein (UniProt Q8N6F8) is 245 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6F8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6F8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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