ADP-ribosylation factor GTPase-activating protein 2 (ARFGAP2)
Homo sapiens — UniProt Q8N6H7
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribosylation factor GTPase-activating protein 2 (ARFGAP2) is a protein from Homo sapiens identified by UniProt accession Q8N6H7, 521 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q8N6H7; gene symbol ARFGAP2.
- Organism: Homo sapiens.
- Length: 521 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, heel bone mineral density and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribosylation factor GTPase-activating protein 2 |
|---|---|
| UniProt accession | Q8N6H7 |
| Gene | ARFGAP2 |
| Organism | Homo sapiens |
| Length | 521 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.10
- heel bone mineral density · score 0.05
- reticulocyte count · score 0.05
- lymphocyte count · score 0.05
- substance abuse · score 0.04
- attention deficit hyperactivity disorder · score 0.04
- antisocial behaviour measurement · score 0.04
- platelet count · score 0.04
- BMI-adjusted hip circumference · score 0.04
- lymphocyte percentage of leukocytes · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6H7-F1 | alphafold | PREDICTED | 65.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6H7.
Amino-acid sequence (521 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARFGAP2?
The strongest Open Targets associations for ARFGAP2 are breast adenocarcinoma, heel bone mineral density, reticulocyte count, lymphocyte count and substance abuse.
How long is the ARFGAP2 protein?
The Homo sapiens ARFGAP2 protein (UniProt Q8N6H7) is 521 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6H7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6H7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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