Lysosomal enzyme trafficking factor (LYSET)
Homo sapiens — UniProt Q8N6I4
Data last refreshed: (UniProt release unknown)
Key facts
Lysosomal enzyme trafficking factor (LYSET) is a protein from Homo sapiens identified by UniProt accession Q8N6I4, 163 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q8N6I4; gene symbol LYSET.
- Organism: Homo sapiens.
- Length: 163 amino acids.
- Top disease associations (Open Targets): dysostosis multiplex, Ain-Naz type, skeletal dysplasia and Skeletal dysplasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysosomal enzyme trafficking factor |
|---|---|
| UniProt accession | Q8N6I4 |
| Gene | LYSET |
| Organism | Homo sapiens |
| Length | 163 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- dysostosis multiplex, Ain-Naz type · score 0.51
- skeletal dysplasia · score 0.37
- Skeletal dysplasia · score 0.37
- Intellectual disability · score 0.26
- nonpapillary renal cell carcinoma · score 0.05
- neoplasm · score 0.02
- cancer · score 0.01
- mucolipidosis type II · score 0.01
- viral disease · score 0.01
- infect · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6I4-F1 | alphafold | PREDICTED | 63.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6I4.
Amino-acid sequence (163 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LYSET?
The strongest Open Targets associations for LYSET are dysostosis multiplex, Ain-Naz type, skeletal dysplasia, Skeletal dysplasia, Intellectual disability and nonpapillary renal cell carcinoma.
How long is the LYSET protein?
The Homo sapiens LYSET protein (UniProt Q8N6I4) is 163 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6I4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6I4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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