Sterile alpha motif domain-containing protein 3 (SAMD3)
Homo sapiens — UniProt Q8N6K7
Data last refreshed: (UniProt release unknown)
Key facts
Sterile alpha motif domain-containing protein 3 (SAMD3) is a protein from Homo sapiens identified by UniProt accession Q8N6K7, 520 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q8N6K7; gene symbol SAMD3.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): reaction time measurement, schizophrenia and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sterile alpha motif domain-containing protein 3 |
|---|---|
| UniProt accession | Q8N6K7 |
| Gene | SAMD3 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- reaction time measurement · score 0.33
- schizophrenia · score 0.32
- PHF-tau measurement · score 0.32
- unipolar depression · score 0.31
- sleep duration · score 0.30
- coronary atherosclerosis · score 0.12
- lean body mass · score 0.06
- Okt4 epitope deficiency · score 0.06
- X-Linked Combined Immunodeficiency Diseases · score 0.05
- combined immunodeficiency with skin granulomas · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6K7-F1 | alphafold | PREDICTED | 76.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6K7.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAMD3?
The strongest Open Targets associations for SAMD3 are reaction time measurement, schizophrenia, PHF-tau measurement, unipolar depression and sleep duration.
How long is the SAMD3 protein?
The Homo sapiens SAMD3 protein (UniProt Q8N6K7) is 520 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6K7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6K7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.