Protein KASH5 (KASH5)
Homo sapiens — UniProt Q8N6L0
Data last refreshed: (UniProt release unknown)
Key facts
Protein KASH5 (KASH5) is a protein from Homo sapiens identified by UniProt accession Q8N6L0, 562 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.
- UniProt accession: Q8N6L0; gene symbol KASH5.
- Organism: Homo sapiens.
- Length: 562 amino acids.
- Top disease associations (Open Targets): azoospermia, genetic non-acquired premature ovarian failure and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein KASH5 |
|---|---|
| UniProt accession | Q8N6L0 |
| Gene | KASH5 |
| Organism | Homo sapiens |
| Length | 562 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (130)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.35
- genetic non-acquired premature ovarian failure · score 0.27
- blood protein measurement · score 0.24
- systemic lupus erythematosus · score 0.10
- multiple sclerosis · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- partial chromosome Y deletion · score 0.06
- primary ovarian insufficiency · score 0.06
- mean platelet volume · score 0.06
- isolated congenital hypogonadotropic hypogonadism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6L0-F1 | alphafold | PREDICTED | 68.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6L0.
Amino-acid sequence (562 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KASH5?
The strongest Open Targets associations for KASH5 are azoospermia, genetic non-acquired premature ovarian failure, blood protein measurement, systemic lupus erythematosus and multiple sclerosis.
How long is the KASH5 protein?
The Homo sapiens KASH5 protein (UniProt Q8N6L0) is 562 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6L0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6L0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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