Transmembrane protein 252 (TMEM252)
Homo sapiens — UniProt Q8N6L7
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 252 (TMEM252) is a protein from Homo sapiens identified by UniProt accession Q8N6L7, 170 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8N6L7; gene symbol TMEM252.
- Organism: Homo sapiens.
- Length: 170 amino acids.
- Top disease associations (Open Targets): creatinine measurement, erythrocyte count and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 252 |
|---|---|
| UniProt accession | Q8N6L7 |
| Gene | TMEM252 |
| Organism | Homo sapiens |
| Length | 170 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.40
- erythrocyte count · score 0.31
- glomerular filtration rate · score 0.30
- red blood cell density measurement · score 0.28
- fibroblast growth factor 23 measurement · score 0.26
- cystatin C measurement · score 0.25
- blood phosphate measurement · score 0.25
- hemoglobin measurement · score 0.25
- serum urea measurement · score 0.25
- gut microbiome measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6L7-F1 | alphafold | PREDICTED | 73.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6L7.
Amino-acid sequence (170 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM252?
The strongest Open Targets associations for TMEM252 are creatinine measurement, erythrocyte count, glomerular filtration rate, red blood cell density measurement and fibroblast growth factor 23 measurement.
How long is the TMEM252 protein?
The Homo sapiens TMEM252 protein (UniProt Q8N6L7) is 170 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6L7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6L7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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