Deubiquitinase OTUD6B (OTUD6B)
Homo sapiens — UniProt Q8N6M0
Data last refreshed: (UniProt release unknown)
Key facts
Deubiquitinase OTUD6B (OTUD6B) is a protein from Homo sapiens identified by UniProt accession Q8N6M0, 293 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q8N6M0; gene symbol OTUD6B.
- Organism: Homo sapiens.
- Length: 293 amino acids.
- Top disease associations (Open Targets): intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies, Intellectual disability and epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Deubiquitinase OTUD6B |
|---|---|
| UniProt accession | Q8N6M0 |
| Gene | OTUD6B |
| Organism | Homo sapiens |
| Length | 293 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies · score 0.75
- Intellectual disability · score 0.48
- epilepsy · score 0.48
- genetic disorder · score 0.47
- neurodegenerative disease · score 0.37
- pulse pressure measurement · score 0.28
- neoplasm · score 0.10
- nonpapillary renal cell carcinoma · score 0.09
- appendicular lean mass · score 0.08
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6M0-F1 | alphafold | PREDICTED | 84.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6M0.
Amino-acid sequence (293 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OTUD6B?
The strongest Open Targets associations for OTUD6B are intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies, Intellectual disability, epilepsy, genetic disorder and neurodegenerative disease.
How long is the OTUD6B protein?
The Homo sapiens OTUD6B protein (UniProt Q8N6M0) is 293 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6M0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6M0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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