Acyl-coenzyme A diphosphatase FITM2 (FITM2)
Homo sapiens — UniProt Q8N6M3
Data last refreshed: (UniProt release unknown)
Key facts
Acyl-coenzyme A diphosphatase FITM2 (FITM2) is a protein from Homo sapiens identified by UniProt accession Q8N6M3, 262 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q8N6M3; gene symbol FITM2.
- Organism: Homo sapiens.
- Length: 262 amino acids.
- Top disease associations (Open Targets): Siddiqi syndrome, diet measurement and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyl-coenzyme A diphosphatase FITM2 |
|---|---|
| UniProt accession | Q8N6M3 |
| Gene | FITM2 |
| Organism | Homo sapiens |
| Length | 262 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- Siddiqi syndrome · score 0.68
- diet measurement · score 0.31
- mean corpuscular volume · score 0.27
- type 2 diabetes mellitus · score 0.13
- esophageal cancer · score 0.10
- monocyte count · score 0.06
- high density lipoprotein cholesterol measurement · score 0.05
- mean reticulocyte volume · score 0.04
- reticulocyte count · score 0.04
- mean corpuscular hemoglobin · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6M3-F1 | alphafold | PREDICTED | 86.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6M3.
Amino-acid sequence (262 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FITM2?
The strongest Open Targets associations for FITM2 are Siddiqi syndrome, diet measurement, mean corpuscular volume, type 2 diabetes mellitus and esophageal cancer.
How long is the FITM2 protein?
The Homo sapiens FITM2 protein (UniProt Q8N6M3) is 262 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6M3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6M3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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